The figure below illustrates OBT's IO discovery process which has provided a unique insight into the cancer - immune cell synapse, highlighting a number of novel IO candidates for cancer therapies.
Cancer tissue
Normal tissue
Novel OBT IO targets specific to tumour microenvironment
Novel IO therapies
Tumor infiltrated lymphocytes (TILs)
Normal immune crlls
Our Approach
“Its compelling to think of the immune system in cancer for three reasons.”
“One is the incredible specificity of the immune system. The second is that the immune system can adapt as the tumor changes. The third one is that you can get memory, and that's the hallmark of the immune system that doesn't exist for any other type of cancer therapy. Once you've generated T cells that can recognise cancer, you've got them basically for the rest of your life. Whereas with every other drug, they kill a bunch of tumor cells and then the drugs go away.”
