Harnessing immune cells to cure cancer.

Redefining the cancer-immune synapse for novel immune checkpoint
mechanisms.
About us
Oxford BioTherapeutics (OBT) is pioneering an innovative approach for the development of First-in-Class Cancer Therapies
3
Partnerships with

Key Innovations
25M
Cash Income in 2022
$$$
Pipeline Opportunities
Strong
BD Pipeline
3
Clinical-stage assets
2
R&D Sites across
the UK and US
3
Partnered Assets
54
Employees
Quick Facts

Clinical-stage oncology company developing novel, first-in-class ADC, TCE
and immunotherapies, focused on serving patients with solid tumors who respond poorly
to PD-1 inhibitors

Underpinned by OGAP(R) (Oxford Genome Anatomy Project), a fully-integrated, proprietary, discovery platform enabling the identification, discovery and validation of novel membrane-bound targets, foe the development of differentiated oncology therapy to overcome existing treatment resistance and address high-risk, underserved patient populations

Operations and know-how located in Oxford (UK) and San Jose (USA), key global biotech and R&D hubs

Partner of choice for global biopharmas seeking tailored drug discovery capabilities
with access to a unique, proprietary database of novel protein targets.

Sustained growth expected as partners continue to extend partnerships through exercising options, and through an ever-growing pipeline of new business development opportunities

Highly scalable platform with tangible avenues for expansion of drug discovery capabilities

Our approach
OBT’s Innovative strategy to Novel Cancer Therapies
(OBT) navigates through several cutting-edge oncology directions to foster the development of novel cancer therapies. These include:
Our Workflow
Innovative Approach
to Novel Cancer Therapies
Proteins Identified and Quantified in OGAP®
Patient Tissue: Quantitative
Membrane Proteomics
OGAP® Target Identification, utilising proteomics, bioinformatics, literature, public data
Putative Targets, Including for ADCs, CAR-Ts, TCEs, mAbs, BiTEs® and IO
Target Validation Workflow using laboratory methods, including tool antibodyvalidation and IHC
Shortlisted
Targets
Target Shortlisting through discussions with collaborator, tailored to specific requirements and drug modality
Validated Targets

and Lead mAbs
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Pipelines
Internal Program Development
Our broad internal clinical and pre-clinical pipeline focuses on ADCs and checkpoint regulators and targets patients with solid tumors who respond poorly to PD-1 inhibitors.
OBT076
ADC
Solid tumors
Discovery
Phase 1
Our lead asset, OBT076, is an innovative Antibody Drug Conjugate (ADC) with a potential dual mechanism of action.
OBT076 / Balstilimab
ADC
Solid tumors
Discovery
Phase 1
OBT076 is demonstrating activity as a monotherapy. In addition, it can also act as a ‘primer’ re-engaging the patient’s immune system while at the same time targeting cancer cells.
OBT698R
IO mAb
Solid tumors
Discovery
Phase 1
OBT698R is a unique immuno-modulatory receptor highly expressed in tumor infiltrating lymphocytes (TILs) of ten different solid tumor types and in activated T cells.
OBT698 / PDL1
IO Biscpecific
Solid tumors
Discovery
Phase 1
Bispecific combining the novel immune-checkpoint regulator, OBT698 with a PDL1 antibody in a single molecule.
OBT700R
IO Biscpecific
Solid tumors
Discovery
Phase 1
T cell engagement of tumor cells in vitro and in patients leads to simultaneous down regulation of the OBT700 ligand and upregulation of PDL1.
OBT700R / PDL1
IO Biscpecific
Solid tumors
Discovery
Phase 1
We have developed a bispecific molecule combining our OBT700 agonist activity with a PDL1 antagonist.
partnerships
Partnered Programs
Our partnered pipeline includes drug candidates that we have out licensed to leading pharmaceutical and biotechnology companies, including Boehringer Ingelheim,Immunogen and Genmab. Our partners are developing one or more drug candidates that we discovered using our OGAP® platform.
View all partnerships
team
The driving force behind Oxford BioTherapeutics innovative trajectory is our adept team that embodies a curated balance of scientific rigor and medical proficiency.
Unveiling Progress
Through diligent research, global clinical alliances,
and strong investment partnerships, we're forging
a path towards innovative cancer therapies
50+ Studies
Oxford BioTherapeutics has orchestrated over 50 studies in oncology to date, reflecting our unwavering commitment to unearthing and cultivating innovative cancer treatment avenues.
30+ Clinics
Our alliance with 30 prime oncology clinics worldwide facilitates access to state-of-the-art medical apparatus and the acumen of preeminent specialists in oncology.
20+ Investors
With over 20 investors, encompassing major pharmaceutical entities and venture capital consortia, we are well-resourced in our endeavor to forge novel therapeutic trajectories for cancer treatmen
News
Interested in what Oxford BioTherapeutics has been up to lately?
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Development
October 4, 2023
FDA grants Fast Track Designation to Boehringer Ingleheim antitumor agent
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Research
July 5, 2023
Oxford BioTherapeutics brings Phase Ib trial with OBT-076 to Europe
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Development
May 25, 2023
Boehringer Ingelheim extends 2020 collab with Oxford BioTherapeutics
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Research
April 26, 2023
The ABCs of ADC Potential
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Partnerships
March 1, 2023
OBT Declared a “Well-deserved Double Award Winner”
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Partnerships
September 28, 2022
OBT Tops the Thames Valley SME 100 Growth Index 2022
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